Philip J Rosenthal Selected Research

Cysteine Proteinase Inhibitors

1/2010	Antimalarial activity of azadipeptide nitriles.
8/2004	Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport.
6/2004	Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites.
12/2003	Antimalarial activities of novel synthetic cysteine protease inhibitors.

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Philip J Rosenthal Research Topics

Disease

232	Malaria 04/2024 - 01/2002
38	Infections 10/2023 - 12/2002
36	Falciparum Malaria (Plasmodium falciparum Malaria) 02/2024 - 02/2003
26	Parasitemia 06/2022 - 05/2006
7	Rupture 01/2011 - 01/2002
6	Fever (Fevers) 11/2021 - 06/2007
6	HIV Infections (HIV Infection) 11/2014 - 01/2006
5	Parasitic Diseases (Parasitic Disease) 01/2022 - 01/2005
5	Reinfection 03/2015 - 02/2003
4	COVID-19 01/2023 - 04/2022
4	Glucosephosphate Dehydrogenase Deficiency 01/2018 - 08/2008
3	Communicable Diseases (Infectious Diseases) 12/2023 - 12/2008
3	African Trypanosomiasis (Nagana) 01/2023 - 09/2009
3	Trachoma 12/2019 - 05/2014
3	Cryptosporidiosis 01/2019 - 12/2008
2	Pregnancy Complications 11/2022 - 01/2018
2	Hemolysis 12/2019 - 09/2004
2	Neglected Diseases 01/2019 - 01/2017
2	Body Weight (Weight, Body) 01/2019 - 11/2012
2	Thalassemia 01/2018 - 11/2017
2	Toxoplasmosis 10/2016 - 12/2008
2	Acute malaria 09/2013 - 05/2012
2	Pruritus (Itching) 11/2012 - 02/2007

Drug/Important Bio-Agent (IBA)

76	Antimalarials (Antimalarial Agents)IBA 03/2024 - 05/2002
39	artemisinin (artemisinine)IBA 04/2024 - 07/2005
34	pyrimethamine drug combination fanasil (Fansidar)FDA Link 02/2024 - 12/2002
30	Cysteine Proteases (Cysteine Protease)IBA 01/2022 - 01/2002
29	Lumefantrine Drug Combination Artemether (Coartem)FDA Link 02/2024 - 05/2006
29	artenimol (dihydroartemisinin)IBA 01/2023 - 05/2007
29	piperaquineIBA 01/2023 - 05/2007
27	Amodiaquine (Camoquin)FDA Link 02/2024 - 12/2002
22	falcipain 2IBA 04/2024 - 04/2002
19	Hemoglobins (Hemoglobin)IBA 01/2018 - 03/2002
18	ArtesunateIBA 02/2024 - 12/2002
17	Chloroquine (Aralen)FDA LinkGeneric 06/2022 - 02/2003
13	Peptide Hydrolases (Proteases)FDA Link 01/2020 - 03/2002
11	InsecticidesIBA 03/2024 - 01/2012
8	PapainIBA 01/2020 - 01/2002
8	falcipain 3IBA 01/2020 - 01/2003
8	Proteins (Proteins, Gene)FDA Link 08/2015 - 03/2002
7	EnzymesIBA 09/2013 - 08/2006
6	Folic Acid AntagonistsIBA 02/2024 - 02/2003
6	Amino Acids FDA Link 01/2023 - 11/2002
6	AntigensIBA 01/2020 - 12/2004
6	Sulfamethoxazole Drug Combination Trimethoprim (Co-Trimoxazole)FDA LinkGeneric 11/2014 - 09/2006
5	Protease Inhibitors (Protease Inhibitor)IBA 01/2022 - 12/2004
5	falcipainIBA 01/2020 - 08/2004
5	Azithromycin (Zithromax)FDA LinkGeneric 12/2019 - 05/2014
5	Lopinavir FDA Link 01/2017 - 11/2011
5	Ritonavir (Norvir)FDA Link 01/2017 - 11/2011
5	insulin receptor-related receptor (IRR)IBA 08/2014 - 12/2004
4	rhodesainIBA 04/2024 - 09/2009
4	VaccinesIBA 11/2020 - 05/2008
4	Merozoite Surface Protein 1 (MSA1)IBA 12/2019 - 02/2003
4	Lumefantrine FDA Link 12/2017 - 08/2009
4	Histidine (L-Histidine)FDA Link 09/2017 - 06/2007
4	Peptides (Polypeptides)IBA 01/2017 - 03/2006
4	Reverse Transcriptase InhibitorsIBA 08/2014 - 11/2012
4	Cysteine Proteinase InhibitorsIBA 01/2010 - 12/2003
3	ArtemisininsIBA 03/2024 - 01/2021
3	efavirenz (Sustiva)FDA Link 01/2023 - 11/2012
3	Pyrethrins (Pyrethroids)FDA Link 10/2022 - 11/2016
3	Pyrimethamine (Daraprim)FDA Link 01/2022 - 11/2004
3	Biomarkers (Surrogate Marker)IBA 12/2019 - 01/2012
3	Heme (Haem)IBA 05/2015 - 10/2010
3	Membrane Proteins (Integral Membrane Proteins)IBA 07/2011 - 12/2002
3	Quinine (Quinson)FDA Link 05/2011 - 07/2009
3	hemozoinIBA 04/2009 - 05/2005
2	NitrilesIBA 04/2024 - 01/2010
2	OrganophosphatesIBA 03/2024 - 10/2022
2	CarbamatesIBA 03/2024 - 10/2022
2	3- (2- methoxyphenyl)- 5- methoxy- 1,3,4- oxadiazol- 2(3H)- oneIBA 10/2023 - 01/2023
2	Interleukin-10 (Interleukin 10)IBA 09/2023 - 12/2019
2	Proguanil (Paludrine)FDA Link 01/2022 - 07/2013
2	Tetrahydrofolate Dehydrogenase (Dihydrofolate Reductase)IBA 01/2022 - 09/2006
2	Immunoglobulin G (IgG)IBA 01/2020 - 01/2012
2	AminoquinolinesIBA 12/2019 - 10/2019
2	2- methyl- 3- (4- phenylpiperidino)propionohydroxamic acid hydrochloride (K 76)IBA 01/2019 - 01/2015
2	Indicators and Reagents (Reagents)IBA 01/2019 - 09/2009
2	GlobinsIBA 11/2017 - 05/2005
2	glucose-6-phosphate dehydrogenase A-IBA 11/2017 - 12/2004
2	Sickle HemoglobinIBA 11/2017 - 12/2004
2	Ligases (Synthetase)IBA 10/2016 - 08/2013
2	8-aminoquinolineIBA 05/2015 - 02/2014
2	Hemin (Panhematin)FDA Link 05/2015 - 04/2015
2	DNA (Deoxyribonucleic Acid)IBA 09/2013 - 08/2013
2	TetracyclinesIBA 07/2013 - 09/2006
2	KininsIBA 02/2013 - 05/2012
2	IronIBA 12/2012 - 11/2010
2	Primaquine FDA Link 03/2012 - 10/2011
2	AntibodiesIBA 01/2012 - 07/2011

Therapy/Procedure

72	Therapeutics 02/2024 - 12/2002
18	Chemoprevention 02/2024 - 07/2014
8	Aftercare (After-Treatment) 03/2015 - 05/2006
4	Drug Therapy (Chemotherapy) 06/2021 - 01/2002
4	Insecticide-Treated Bednets 01/2020 - 10/2007
4	Art Therapy 04/2014 - 04/2012
3	Mass Drug Administration 11/2022 - 09/2017
2	Microspheres (Microsphere) 10/2016 - 08/2014
2	Oral Administration 12/2013 - 11/2012